Polynucleotides are rapidly becoming one of the most talked-about skin booster and skin rejuvenation treatments in cosmetic dermatology. Interest has surged in these innovative injectable therapies, with patients searching for more information on what polyneucleotides are and what results they can achieve. Unlike traditional fillers that add volume, polynucleotide injections work by regenerating the skin from within—stimulating collagen, elastin, and deep hydration.
Leading consultant dermatologist in London, Dr Derrick Phillips, explains how polynucleotide treatments improve skin quality, reduce fine lines, strengthen thinning skin, and rejuvenate delicate areas, such as the under-eyes. This article breaks down what polynucleotides are, how they work, treatment benefits, and what patients can expect when exploring this modern skin boosting injectable.
What Are Polynucleotides?
Polynucleotides (PNs) are highly purified DNA fragments used in regenerative dermatology. Once injected into the skin, these molecules:
- Stimulate fibroblasts (the cells responsible for collagen and elastin production)
- Improve skin density and firmness
- Support tissue repair and remodelling
- Enhance hydration by attracting and binding water
- Reduce pore size, fine lines, and wrinkles
Unlike synthetic fillers that provide instant volume, PNs aim to restore the skin’s natural architecture over time. They help create a healthier, stronger foundation for long-term skin rejuvenation.
In this Marie Claire article, Dr Derrick Phillips highlights polynucleotides as part of a growing movement known as “collagen banking”—a preventative approach where patients invest early in their skin’s future firmness and elasticity before more aggressive ageing changes occur.
How Do Polynucleotides Work?
Polynucleotides initiate a cascade of regenerative activity within the skin as follows:
1. Fibroblast Stimulation
Fibroblasts are the cells that produce collagen and elastin — two essential proteins that keep skin firm, smooth, and youthful. Polynucleotides activate dormant fibroblasts, increasing the production of:
- Collagen (structure and strength)
- Elastin (bounce and flexibility)
- Glycosaminoglycans (hydration and volume)
This leads to improved skin density and texture over time.
2. Deep Hydration
PNs have strong water-binding capabilities. They attract and retain moisture within the dermis, improving plumpness and elasticity. Patients often notice an immediate increase in hydration, followed by longer-term structural improvements.
3. Repair and Regeneration
Polynucleotides reduce inflammation and oxidative damage, helping repair environmentally stressed or injured skin. They support wound healing, making them suitable for thin, fragile, or ageing skin.
Polynucleotide Injections vs. Traditional Fillers
Many patients assume polynucleotides are a type of filler, but the two serve completely different purposes.
Dermal Fillers:
- Add volume
- Sculpt or contour features
- Provide instant, structural results
- Best for cheeks, lips, deep folds, jawline
Polynucleotides:
- Improve skin quality
- Stimulate the body’s own collagen and elastin
- Increase hydration, density, and resilience
- Soften pores, fine lines, and crêpey texture
- Deliver gradual, regenerative results
Polynucleotides are ideal for patients who want a natural, restored appearance—not a filled or overdone look. They work beautifully alongside fillers and anti-wrinkle treatments, acting as a foundation for long-term skin health.
Benefits of Polynucleotide Treatment
- Increased Skin Density & Firmness: The regenerative effect thickens and strengthens the dermis, improving overall skin structure.
- Improved Fine Lines & Wrinkles: By boosting collagen and elastin, polynucleotides soften early signs of ageing without altering facial shape.
- Reduction in Pore Size: Enhanced collagen support tightens and refines enlarged pores, contributing to smoother texture.
- Enhanced Hydration & Plumpness: Their strong water-binding ability provides long-lasting hydration and radiance.
- More Resilient, Balanced Skin: Polynucleotides help calm inflammation and improve skin’s ability to heal and regenerate.
- Suitable for All Skin Types: Especially beneficial for delicate or mature skin, skin damaged by sun exposure, or skin recovering from aesthetic procedures.
Polynucleotide Treatment Process
Polynucleotides are typically administered via micro-injections across targeted areas of the face or neck.
Common Treatment Areas:
- Face
- Under-eyes
- Neck and décolletage
- Hands
Typical Treatment Schedule:
- 2–3 sessions spaced 3–4 weeks apart
- Maintenance every 6–12 months
- Results build gradually over several weeks
Downtime:
Minimal. Patients may experience slight redness, pinpoint marks, or mild swelling for 24–48 hours.
Who Is an Ideal Candidate?
Polynucleotides are excellent for patients who:
- Want to improve skin quality rather than add volume
- Have early signs of ageing
- Notice thinning skin or poor skin density
- Want to reduce pore size or fine lines
- Prefer natural results
- Want regenerative treatment with minimal downtime
- Are undergoing “collagen banking” in their 20s–40s
- They are safe for all skin tones and compatible with most skincare and treatment plans.
Are Polynucleotides Safe?
Yes—when administered by a qualified dermatologist, like Dr Derrick Phillips. The fish-derived DNA molecules are highly purified and undergo rigorous testing. Side effects are typically mild and temporary, including swelling or small injection bumps.
This procedure is not suitable for:
- People with certain fish allergies
- Those who are pregnant or breastfeeding (as a precaution)
Your dermatologist will assess your suitability during a consultation.
Polynucleotide Treatment Cost
The cost of polynucleotide treatment at Dr Derrick Phillips’ clinic starts from £450 per area, reflecting the use of high-quality, medical-grade polynucleotides and the expertise required to administer them safely and effectively. Pricing varies based on the treatment area, number of sessions recommended, and whether the patient is addressing general skin rejuvenation, under-eye crepiness, or more advanced collagen support.
While polynucleotide injections are an investment, the regenerative benefits—improved skin density, hydration, fine line reduction, and long-term collagen stimulation—make them a cost-effective option compared to procedures that simply add temporary volume. During your consultation, Dr Phillips will provide a personalised treatment plan and transparent pricing tailored to your skin needs.
How Do Polynucleotides Fit Into a Regenerative Skin Treatment Plan?
Polynucleotides pair extremely well with other treatments. They can be combined with:
- Microneedling to enhance collagen stimulation
- Laser treatments to improve texture and pigmentation
- Anti-wrinkle injections for expression lines
- Dermal fillers for structural support
- Medical-grade skincare for optimised skin health
This combined regenerative approach is becoming a gold standard in modern cosmetic dermatology. Dr Derrick Phillips can help you create a customised plan for your goals.